Endocrine Abstracts

Adrenocortical carcinoma (ACC) is a rare malignancy. Authors present three cases of even less commonly encountered manifestation of ACC. Case 1: A 39-year-old male, with decompensated hypertension, was admitted to Department of Endocrinology due to a large tumor of the left adrenal gland (65 mm) revealed in the CT of the abdomen. Non-contrast attenuation was 35HU. After performing MRI with chemical shift, tumor was classified as non-adenoma as there was no significant loss of ...

In patients with Graves disease and Graves’ orbitopathy (GO), the diagnosis was based on clinical activity score (CAS), TSH-receptor antibodies, orbital MRI assesment. Thyreometabolic status was assessed by TSH, FT4, FT3. Before the administration of high-dose intravenous glucocorticoids oral glucose tolerance test (OGTT) was performed obligatory. The patient with confirmed diabetes were excluded form the study. Acute hyperglycaemia was diagnosed at the glucose concentrat...

The observed increase in the incidence of Hashimoto’s thyroiditis (HT) requires the research on environmental factors that may initiate or model its course. There have been reports of the impact of vitamin D3 deficiency on HT development.Objective: To assess the degree of deficiency of 25OHD3 and the relationship between the disease duration and 25OHD3 levels in patients with HT.Material and methods: 310 people were enrolled i...

IntroductionDiagnostics of thyroid dysfunctions is frequently based on the measurements of TSH serum concentration only. Currently, due to a tendency to minimize stressful situations for a child (such as venipuncture to take a blood sample), some tests (i.e. TSH assessment) are performed at the Primary Healthcare Centre while other diagnostic tests (e.g. during an infection) are run. If TSH serum concentration is outside the reference range, it leads to ...

Background: Graves disease with elevated Immunoglobulin G4 serum concentration is a novel subtype of Graves disease (GD), which seems to be particularly associated with Graves orbitopathy (GO). It occurs in 17.6% of patients with GO and 5.4% of patients with GD without GO. In this study, we compare multiple magnetic resonance imaging (MRI) features of GO with elevated IgG4 serum concentration (IgG4-GO) with the classic GO subtype without IgG4 elevation. No such research has be...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. In recent years revised diagnostic criteria for PCOS in adolescent females were disseminated. These new criteria notably encompass the specification of irregular menstrual cycles and hyperandrogenism, with the exclusion of polycystic ovarian morphology. In our study, we aimed to verify whether the clinical presentation of adolescent patients meeting the new criteria is associate...

Introduction: Thoracic Endometriosis Syndrome (TES) is characterized by clinical symptoms associated with menstruation (eg, catamenial pneumothorax (CP), chest pain, and others) not obligatorily requiring histological confirmation. The treatment is burdened with frequent recurrences. This study aimed to characterize the treatment of women with TES and assess the concomitant diseases.Methods: A developed online survey was published in patients’ suppo...

Introduction: Crooke’s cell adenomas (CCA) are a rare type of pituitary neoplasm, associated with Cushing’s disease. They are characterised by accumulation of perinuclear cytokeratin filaments, appearing distinctly hyaline in hematoxylin and eosin (HE) staining (Crooke’s hyaline change). Due to their rarity, the management and treatment remain a challenge.Clinical case: A 33-year-old male patient, presented sudden visual impairment, no sig...

Recently, 59 percent of European adults was diagnosed with obesity or overweight according to the 2022 Regional Obesity Report presented by the World Health Organization (WHO). Thus, insight into factors implicated in overweight and obesity may have important therapeutic implications. Interestingly, increased cortisol secretion and psychosocial stress have been demonstrated to be related with body weight-dependent insulin resistance and beta cells failure. Thus, the study was ...

Objective: Women with Hashimoto thyroiditis (HT) could have fertility problems. Serum anti-Müllerian hormone (AMH), which reflects functional ovarian reserve, is decreased in women with HT. The aim of the present study was to investigate the relation between serum levels of AMH and insulin resistance in women with HT compared to control group. Patients and methods: We examined 193 women: 37 subjects with HT, without previous history of treatment wit...